Methods: The study group included 35 patients (15 women, 20 men, 65.8 7.1 years) with NSCLC in stage IIIB (n = 16, 45.7%) and IV (n = 19,54.3%) who were treated with nivolumab. Thank you for posting it, I agree we all need as much knowledge as we can get! [6] Venditti P, Di Stefano L, Di Meo S: Oxidative stress in cold induced hyperthyroid state. Capmatinib (Tabrecta) is the first FDA-approved MET-targeting medication for treating metastatic NSCLC. El almacenamiento o acceso tcnico que es utilizado exclusivamente con fines estadsticos. The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. 1). Perhaps she and I could co-author? 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). Cookie Notice El almacenamiento o acceso tcnico es necesario para crear perfiles de usuario para enviar publicidad, o para rastrear al usuario en una web o en varias web con fines de marketing similares. Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. The aim of the study was to assess the occurrence and nature of immune-related endocrine adverse events (irAEs) among patients with non-small-cell lung cancer (NSCLC) treated with nivolumab. I am going to go for a walk with my dog :)). Metab.87 (2): 48999. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. PLoSone 2011, 11:e27547. Note: Only a member of this blog may post a comment. So I will leave it as a simple thank you for passing this along. Endocrinology 2008, 149:22412250. She wrote about a product called Thyrtophin PMG. Monaldi Arch Chest Dis 2003, 59:140145. The Dangers of Tylenol: Is it Time to for the FDA Chile: Psychiatrist Leads Crusade To Legalize Mari 13 Things Sure To Slow Down Your Metabolism. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. As a never smoker I truly wish I smoked so I could just say that's why I got this. They compared sale of, "However, the impression we get from our experience, Health, Studies, Supps & Pharmaceuticals. I am convinced that my lung cancer is related to the thyroid/auto immune issues I've had for years. Different strokes for different folks for sure! by D.ap Tue Feb 21, 2017 10:40 am, Powered by phpBB Forum Software phpBB Limited. undefined will no longer be visible to you including posts, replies, and photos. Endocrinology 1985, 117:12011208. LifeGivingStore.comRed Light Therapy - Hydrogen Water Generators - Cascara Sagrada - Vitamins, Minerals & Amino Acid Supplements - Cocoa Products - Handcrafted Soaps - Grass Fed Organs & Glandulars - Nano Soma. JavaScript is disabled. Forgot account? However, they pointed out that the opposite was recently described, and that "hypothyroidism reduces theaggressiveness of some cancers because of the presence of thyroid hormone receptors oncancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness ofcancers."[1]. "Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)", International Journal of Human Nutrition and Functional Medicine, Osteoporosis Is Scurvy of the Bone, Not Calcium Deficiency, 6 Bodily Tissues That Can Be Regenerated Through Nutrition, 7 Simple Ways to Unclog Your Arteries Naturally, Herbal Cream Clears 87.7% of HPV Cases Naturally, How WHOLE Turmeric Heals the Damaged Brain. They found no significant correlation between T4 sales and breast, colorectal and gastric cancers, but did find a significant correlation for lung cancer (p < 0.05) corrected for smoking and age. rocket fuel, pesticides, fluoride, which induce low thyroid function. They only reappear when I need to fine tune the medication. The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. Assessment of oxidative stress and its balance has not been taken into consideration up to now as it should be. For more, visitGreenMedInfo.comand Facebook.com/GreenMedInfo, or sign up forGreenMedInfos free e-Newsletter. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to replacement therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. As I am the caregiver for my dad who has Stage IV lung Cancer, I hope more research can be done on this topic soon. Medical Authoritys System Kills: FDA-Approved Dru Cognitive Impairment, Memory Loss and Alzheimer's Soy Lecithin: How It Negatively Affects Your Healt Cannabis Oil Cures Cancer -Lincoln Horsley's Story New Information Dissolves Illusions About Vaccines Grounding Helps Thin Dangerously Thick Blood and F Tart Cherries Relieve Osteoarthritis Pain, Lieberman's Massive Connections To Big Pharma, Utopian 'Harvest Your Own' Groceries Coming Up. [13] Hollowell JG, Staehling NW, Flanders WD, et al. One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore back up causing excessive T4 activity, i.e. Privacy Policy. PMID: 15253676. This relatively symptom-free reservoir of hypothyroid cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. I have been reading Izabella Wentz. ", Cure Alveolar Soft Part Sarcoma International, COMPLETED - Dana Farber Vaccine Clinical Trial (GVAX), Axitinib and Pembrolizumab (Keytruda) in Miami, US, TECENTRIQ (atezolizumab) by Genentech, Treatment of Non-Resectable Primary Tumor, Immune checkpoint inhibitors ICI (PD-1 and PD-L1 targeting drugs), Toxicity, problems and potentiation strategies, Treatment response criteria and evaluation/scanning problems/rare cases, treatment discontinuation/re-treatment, Side effects/complications of the local ablations, High intensity focused ultrasound (HIFU), Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, http://www.greenmedinfo.com/blog/study- ng-cancers. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as "hypothyroidism"? Endocrinology 2008, 149:22412250. I wonder if only t3 treatments are preferable than t4 and t3 ? A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. Endocrinol. I can understand why tennis 123 wrote, "I have so much to say about this I could write a book". Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the low thyroid, why call chemical poisoning hypothyroidism? Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: Recently T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. Is Drug-Based Medicine a Form of Human Sacrifice? [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. Join the Patient & Caregiver Network. Increased sleepiness. Article published in Wakeup-World.Com. You may not notice signs or symptoms of the disease. A couple of caveats to note in this study: The authors found a statistical correlation between the increase in sales of the thyroid medicine Synthroid, and an increase in lung cancer in Italy. It took over five years before the someone figured out my ongoing symptoms were due to hypothyroidism. The estimated 2.3 million new cases indicate that 1 in every 8 cancers diagnosed in . The study included more than 128,000 veterans aged 18 to 26 and found that, just 30.2% of females and 18.7% of males had received HPV vaccination. Sin un requerimiento, el cumplimiento voluntario por parte de tu Proveedor de servicios de Internet, o los registros adicionales de un tercero, la informacin almacenada o recuperada slo para este propsito no se puede utilizar para identificarte. It does not necessarily imply one thing caused the other. Log In. "A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' I have posted the link now. When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. millions treated for hypothyroidism at risk for lung cancer. Eventually, the decline in thyroid hormone production can result in any of the following: Fatigue and sluggishness. According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called 'subclinical' hypothyroidism only detected via blood work. You must log in or register to reply here. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. I don't believe there are thousands of people on to high a dose of t4, so why does it feel they are hyper? Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. They found no significant correlation between T4 sales and breast, colorectal and gastriccancers, but did find a significant correlation for lung cancer (p < 0.05) corrected forsmoking and age. Symptoms. View the data on our Hypothyroidism Research page. A total of 425 inpatients with malignant tumors were treated with ICIs at PUMCH during the study period. There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. En 3 minutos recibirs en tu email COMPLETAMENTE GRATIS todo lo que necesitas para aumentar las ventas de tu empresa. If you are already a member, please, Levothyroxine and lung cancer in females: the importance of oxidative stress, recent announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs. Assessment of oxidative stress and its balance has not been taken into consideration up to now as it should be.". There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. Millions of people who were not only wrongly diagnosed with cancers and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. The Remarkable Heart-Friendy Properties of Avocados. Overtreatment, of course, is the hallmark danger of overdiagnosis. Baked or Fried avocado fries [Vegetarian]. Share your experience, learn from others. Here members can share stories, find important information and learn from the experiences of others like themselves. Results indicate that treatment with levothyroxine was linked with significantly increased mortality (hazard ratio = 1.19). Heart problems. [4] Ratcliffe JG, Stack BH, Burt RW, Radcliffe WA, Spilg WG, Cuthbert J, Kennedy RS: Thyroid function in lung cancer. Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. Or, simply look at what the young-adult, T-score based definition of osteoporosis and osteopenia has done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. I bet in the previous discussion, if there was one, we would have concluded it was likely that it was because people are generally not put on enough levothyroxine. Brit Med J 1978, 1:210212. Sayer Ji is the founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, and SteeringCommittee Memberof the Global Non-GMO Foundation. [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. Just another excuse for keeping us on doses that are too low. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the "low thyroid," why call chemical poisoning "hypothyroidism"? Another recently approved drug is tepotinib (Tepmetko). Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer J Exp Biol 2010, 213:28992911. http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-l Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, Iodine Supplementation Support by VWT Team. In addition, untreated hypothyroidism is associated with a gradual decline in cognitive function and memory. Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). Objectives: To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism. I have always found this condition a riddle. It is very tormenting (for me anyhow) to not know why I got this disease. If people do not wish to find out all they can about their disease that is fine too. Symptoms can include fatigue, shortness of breath with exercise, and decreased ability to exercise. Or, simply look at what the young-adult,T-score based definition of osteoporosis and osteopeniahas done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. Is This the Real Reason You're Exhausted All the T Why An Alkaline Approach Can Successfully Treat Ca We're Losing the War on Cancer- Here's Why. But what can be done for patients who are at low A place for patients and relatives. In 2020 alone, there were more than 2.2 million new cases and 1.8 million deaths from lung cancer globally. Whether it should be treated remains controversial. [4] Ratcliffe JG, Stack BH, Burt RW, Radcliffe WA, Spilg WG, Cuthbert J, Kennedy RS: Thyroid function in lung cancer. SayerJiis founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, SteeringCommittee Memberof the Global Non-GMO Foundation. Even in the mildest form, hypothyroidism affects the heart. [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. Si as lo deseas puedes revisar el resto de nuestros contenidos para encontrar lo que buscabas o directamente utilizar nuestro buscador. Is so taking anti oxidants might be an idea. Hypothyroidism reduces respiratory drive and can cause obstructive sleep apnea or pleural effusion, while hyperthyroidism increases respiratory drive and can cause dyspnea on exertion. Very interesting article, thank you for sharing. There are many links attached. This article is copyrighted by GreenMedInfo LLC, 2013, Some features are currently member only features. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. [4], More recently DI activity in lung cancer was found to be lower than in peripheral lung tissue.[5]. hyperthyroidism. I've been on synthroid for 20+ years, scary. As you know, I appreciate people posting links that help us learn more about lung cancer, too. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. Just for entertainment value take a look at some more dodgy correlations : I rather liked the correlation between consumption of orange marmalade and birth rate - in the years after the second world war if I remember correctly.
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